Wide Dynamic Range
The Corona ultra is unique in that it allows quantitation across a range that exceeds four orders of magnitude. This wide dynamic range provides significant advantages for measurement of an analyte and low-level impurities in a single run. In the forced degradation example below, trace levels of degradant are found at the 0.19% level. The wide dynamic range means that the low level impurity, and the API (Amikacin) can be measured in the same run. With response independent of structure, relative levels can be assessed even without knowing the identity of the peak.